MIROTECA

Siewert classification of esophagogastric junction adenocarcinoma

Reviewed by doctors · Last reviewed: October 2026▶ Play today's clinical caseMedicinedle, the medical Wordle · 6 tries · free
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Diagram of the distal esophagus and stomach with a centimeter ruler marking the zones of Siewert types I, II and III relative to the esophagogastric junction
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Free to use for study and teaching with attribution to MIROTECA · terms of use

What is measured is the position of the tumor CENTER relative to the cardia.

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What the diagram shows

The distal esophagus opens into the stomach at the esophagogastric junction (the horizontal line). The ruler on the left marks centimeters above and below that line, and the three colored rectangles are the zones of each type.

Siewert classifies adenocarcinoma of that region by where the center of the tumor lies, not its edge.

The detail that settles it

The classification is used to plan surgery. Type I behaves like distal esophageal cancer, often arising on Barrett's esophagus, and is treated as such (esophagectomy). Type III behaves like gastric cancer and is treated with gastrectomy. Type II sits in between, and the technique depends on its extent.

Current TNM staging follows a similar criterion: tumors whose center lies 2 cm or less from the cardia and that involve it are staged as esophageal.

Common mistakes

The most common slip is applying Siewert to squamous cell carcinoma: the classification is only for adenocarcinoma of the junction. Another is measuring from the edge of the tumor instead of its center.

The esophagogastric junction should not be confused with the diaphragmatic hiatus: in a hiatal hernia they can be several centimeters apart.

In exam questions

Questions usually give the distance from the tumor to the cardia at endoscopy and ask for the type or the indicated surgery. The three bands of the diagram solve it.

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